pentobarbital will lessen the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lack of, or reduced response to tofacitinib could arise when coadministered with potent CYP3A4 inducersWarning with use during surgeries or processes in youngsters more youthful than three yr or in Expecting Gi